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Unfortunately, suchdocuments are often dif?cult to apply at the bedside because they do not containinstructions that can be applied in the present clinical situation (Teno et al. Edith probably has a chronically high PCO2, making a lowPO2 her stimulus to breathe. Reductive dehalogenation of carbontetrachloride and halothane (chlorine and bromine loss,respectively) by cytochrome P450 is such an example, andthis one-electron reduction by cytochrome P450 produces acarbon-centered radical that sets the stage for lipid peroxida-tion and the membrane damage associated with thesepotentially hepatotoxic molecules

Reductive dehalogenation of carbontetrachloride and halothane (chlorine and bromine loss,respectively) by cytochrome P450 is such an example, andthis one-electron reduction by cytochrome P450 produces acarbon-centered radical that sets the stage for lipid peroxida-tion and the membrane damage associated with thesepotentially hepatotoxic molecules.
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